# Cervical cancer **Name**: Cervical cancer **Description**: Framework for a 4-stage cervical cancer cascade model, with vital dynamics and new cases ## Contents - [Compartments](#compartments) - [Characteristics](#characteristics) - [Parameters](#parameters) - [Interactions](#interactions) - [Cascades](#cascades) ## Compartments ### Compartment: Source - Code name: `source` - Is source - Does not appear in the databook - Description: - Data entry guidance: ### Compartment: Without cervical cancer - Code name: `sus` - Does not appear in the databook - Description: - Data entry guidance: ### Compartment: Undiagnosed - Code name: `undx` - Does not appear in the databook - Description: - Data entry guidance: ### Compartment: Screened - Code name: `scr` - Does not appear in the databook - Description: - Data entry guidance: ### Compartment: Diagnosed - Code name: `dx` - Does not appear in the databook - Description: - Data entry guidance: ### Compartment: Treated - Code name: `tx` - Does not appear in the databook - Description: - Data entry guidance: ### Compartment: Dead (other) - Code name: `dead` - Is sink - Does not appear in the databook - Description: - Data entry guidance: ### Compartment: Dead (cervical cancer) - Code name: `dead_cc` - Is sink - Does not appear in the databook - Description: - Data entry guidance: ## Characteristics ### Characteristic: Population size - Code name: `alive` - Value can be used for calibration - Includes: - Without cervical cancer - Undiagnosed - Screened - Diagnosed - Treated - Appears in the databook - Databook values will be used for model initialization - Description: - Data entry guidance: ### Characteristic: Estimated number of women with cervical cancer - Code name: `all_people` - Value can be used for calibration - Includes: - Undiagnosed - Screened - Diagnosed - Treated - Appears in the databook - Databook values will be used for model initialization - Description: - Data entry guidance: ### Characteristic: Estimated number of women with cervical cancer who have ever been screened - Code name: `all_screened` - Value can be used for calibration - Includes: - Screened - Diagnosed - Treated - Appears in the databook - Databook values will be used for model initialization - Description: - Data entry guidance: ### Characteristic: Estimated number of women with cervical cancer who have ever been diagnosed - Code name: `all_dx` - Value can be used for calibration - Includes: - Diagnosed - Treated - Appears in the databook - Databook values will be used for model initialization - Description: - Data entry guidance: ### Characteristic: Estimated number of women being treated for cervical cancer - Code name: `all_tx` - Value can be used for calibration - Includes: - Treated - Appears in the databook - Databook values will be used for model initialization - Description: - Data entry guidance: ## Parameters ### Parameter: Annual number of births - Code name: `birth_rate` - Units/format: number - Value restrictions: At least 0 - Contributes to transitions from: - "Source" to "Without cervical cancer" - Default value: None - Appears in the databook - Description: - Data entry guidance: ### Parameter: Estimated number of new cervical cancer cases annually - Code name: `num_acq` - Units/format: number - Value restrictions: At least 0 - Default value: None - Appears in the databook - Used to compute: - "Acquisition rate" - Description: - Data entry guidance: ### Parameter: Acquisition rate - Code name: `acq_rate` - Value can be used for calibration - Units/format: probability - Value restrictions: 0-1.0000 - Contributes to transitions from: - "Without cervical cancer" to "Undiagnosed" - Default value: None - Does not appear in the databook - This parameter's value is computed by a function: `num_acq/max(sus,num_acq)` - Depends on: - "Estimated number of new cervical cancer cases annually" - "Without cervical cancer" - Description: - Data entry guidance: ### Parameter: Annual number screened - Code name: `num_screen` - Units/format: number - Value restrictions: At least 0 - Default value: None - Appears in the databook - Used to compute: - "Annual number screened positive" - Description: - Data entry guidance: ### Parameter: Screening yield - Code name: `screen_yield` - Units/format: probability - Value restrictions: 0-1.0000 - Default value: None - Does not appear in the databook - This parameter's value is computed by a function: `undx/(undx+sus)` - Depends on: - "Without cervical cancer" - "Undiagnosed" - Used to compute: - "Annual number screened positive" - Description: - Data entry guidance: ### Parameter: Annual number screened positive - Code name: `pos_screen` - Units/format: number - Value restrictions: At least 0 - Default value: None - Does not appear in the databook - This parameter's value is computed by a function: `num_screen*screen_yield` - Depends on: - "Annual number screened" - "Screening yield" - Used to compute: - "Screening sensitivity" - Description: - Data entry guidance: ### Parameter: Screening sensitivity - Code name: `screen` - Value can be used for calibration - Units/format: probability - Value restrictions: 0-1.0000 - Contributes to transitions from: - "Undiagnosed" to "Screened" - Default value: None - Does not appear in the databook - This parameter's value is computed by a function: `pos_screen/max(undx,pos_screen)` - Depends on: - "Annual number screened positive" - "Undiagnosed" - Description: - Data entry guidance: ### Parameter: Annual number of new diagnoses - Code name: `num_diag` - Units/format: number - Value restrictions: At least 0 - Default value: None - Appears in the databook - Used to compute: - "Probability of a positive confirmation following screening" - Description: - Data entry guidance: ### Parameter: Probability of a positive confirmation following screening - Code name: `diag` - Value can be used for calibration - Units/format: probability - Value restrictions: 0-1.0000 - Contributes to transitions from: - "Screened" to "Diagnosed" - Default value: None - Does not appear in the databook - This parameter's value is computed by a function: `num_diag/max(scr,num_diag)` - Depends on: - "Screened" - "Annual number of new diagnoses" - Description: - Data entry guidance: ### Parameter: Annual number newly initiated onto treatment - Code name: `num_initiate` - Units/format: number - Value restrictions: At least 0 - Default value: None - Appears in the databook - Used to compute: - "Initiation rate" - Description: - Data entry guidance: ### Parameter: Initiation rate - Code name: `initiate` - Value can be used for calibration - Units/format: probability - Value restrictions: 0-1.0000 - Contributes to transitions from: - "Diagnosed" to "Treated" - Default value: None - Does not appear in the databook - This parameter's value is computed by a function: `num_initiate/max(dx,num_initiate)` - Depends on: - "Diagnosed" - "Annual number newly initiated onto treatment" - Description: - Data entry guidance: ### Parameter: Mortality rate - Code name: `death` - Units/format: probability - Value restrictions: 0-1.0000 - Contributes to transitions from: - "Without cervical cancer" to "Dead (other)" - "Undiagnosed" to "Dead (other)" - "Screened" to "Dead (other)" - "Diagnosed" to "Dead (other)" - "Treated" to "Dead (other)" - Default value: 0.015 - Appears in the databook - Description: - Data entry guidance: ### Parameter: Mortality rate for those with untreated cervical cancer - Code name: `death_cc` - Units/format: probability - Value restrictions: 0-1.0000 - Contributes to transitions from: - "Undiagnosed" to "Dead (cervical cancer)" - "Screened" to "Dead (cervical cancer)" - "Diagnosed" to "Dead (cervical cancer)" - Default value: 0.05 - Appears in the databook - Description: - Data entry guidance: ## Interactions ## Cascades ### Cascade: Cervical cancer cascade - Description: - Stages: - All women with cervical cancer - Estimated number of women with cervical cancer - Ever screened - Estimated number of women with cervical cancer who have ever been screened - Ever diagnosed - Estimated number of women with cervical cancer who have ever been diagnosed - Currently treated - Estimated number of women being treated for cervical cancer