Cervical cancer

Name: Cervical cancer

Description: Framework for a 4-stage cervical cancer cascade model, with vital dynamics and new cases

Compartments

Compartment: Source

  • Code name: source

  • Is source

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Without cervical cancer

  • Code name: sus

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Undiagnosed

  • Code name: undx

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Screened

  • Code name: scr

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Diagnosed

  • Code name: dx

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Treated

  • Code name: tx

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Dead (other)

  • Code name: dead

  • Is sink

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Dead (cervical cancer)

  • Code name: dead_cc

  • Is sink

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Characteristics

Characteristic: Population size

  • Code name: alive

  • Value can be used for calibration

  • Includes:

    • Without cervical cancer

    • Undiagnosed

    • Screened

    • Diagnosed

    • Treated

  • Appears in the databook

  • Databook values will be used for model initialization

  • Description:

  • Data entry guidance:

Characteristic: Estimated number of women with cervical cancer

  • Code name: all_people

  • Value can be used for calibration

  • Includes:

    • Undiagnosed

    • Screened

    • Diagnosed

    • Treated

  • Appears in the databook

  • Databook values will be used for model initialization

  • Description:

  • Data entry guidance:

Characteristic: Estimated number of women with cervical cancer who have ever been screened

  • Code name: all_screened

  • Value can be used for calibration

  • Includes:

    • Screened

    • Diagnosed

    • Treated

  • Appears in the databook

  • Databook values will be used for model initialization

  • Description:

  • Data entry guidance:

Characteristic: Estimated number of women with cervical cancer who have ever been diagnosed

  • Code name: all_dx

  • Value can be used for calibration

  • Includes:

    • Diagnosed

    • Treated

  • Appears in the databook

  • Databook values will be used for model initialization

  • Description:

  • Data entry guidance:

Characteristic: Estimated number of women being treated for cervical cancer

  • Code name: all_tx

  • Value can be used for calibration

  • Includes:

    • Treated

  • Appears in the databook

  • Databook values will be used for model initialization

  • Description:

  • Data entry guidance:

Parameters

Parameter: Annual number of births

  • Code name: birth_rate

  • Units/format: number

  • Value restrictions: At least 0

  • Contributes to transitions from:

    • “Source” to “Without cervical cancer”

  • Default value: None

  • Appears in the databook

  • Description:

  • Data entry guidance:

Parameter: Estimated number of new cervical cancer cases annually

  • Code name: num_acq

  • Units/format: number

  • Value restrictions: At least 0

  • Default value: None

  • Appears in the databook

  • Used to compute:

    • “Acquisition rate”

  • Description:

  • Data entry guidance:

Parameter: Acquisition rate

  • Code name: acq_rate

  • Value can be used for calibration

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Contributes to transitions from:

    • “Without cervical cancer” to “Undiagnosed”

  • Default value: None

  • Does not appear in the databook

  • This parameter’s value is computed by a function: num_acq/max(sus,num_acq)

  • Depends on:

    • “Estimated number of new cervical cancer cases annually”

    • “Without cervical cancer”

  • Description:

  • Data entry guidance:

Parameter: Annual number screened

  • Code name: num_screen

  • Units/format: number

  • Value restrictions: At least 0

  • Default value: None

  • Appears in the databook

  • Used to compute:

    • “Annual number screened positive”

  • Description:

  • Data entry guidance:

Parameter: Screening yield

  • Code name: screen_yield

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Default value: None

  • Does not appear in the databook

  • This parameter’s value is computed by a function: undx/(undx+sus)

  • Depends on:

    • “Without cervical cancer”

    • “Undiagnosed”

  • Used to compute:

    • “Annual number screened positive”

  • Description:

  • Data entry guidance:

Parameter: Annual number screened positive

  • Code name: pos_screen

  • Units/format: number

  • Value restrictions: At least 0

  • Default value: None

  • Does not appear in the databook

  • This parameter’s value is computed by a function: num_screen*screen_yield

  • Depends on:

    • “Annual number screened”

    • “Screening yield”

  • Used to compute:

    • “Screening sensitivity”

  • Description:

  • Data entry guidance:

Parameter: Screening sensitivity

  • Code name: screen

  • Value can be used for calibration

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Contributes to transitions from:

    • “Undiagnosed” to “Screened”

  • Default value: None

  • Does not appear in the databook

  • This parameter’s value is computed by a function: pos_screen/max(undx,pos_screen)

  • Depends on:

    • “Annual number screened positive”

    • “Undiagnosed”

  • Description:

  • Data entry guidance:

Parameter: Annual number of new diagnoses

  • Code name: num_diag

  • Units/format: number

  • Value restrictions: At least 0

  • Default value: None

  • Appears in the databook

  • Used to compute:

    • “Probability of a positive confirmation following screening”

  • Description:

  • Data entry guidance:

Parameter: Probability of a positive confirmation following screening

  • Code name: diag

  • Value can be used for calibration

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Contributes to transitions from:

    • “Screened” to “Diagnosed”

  • Default value: None

  • Does not appear in the databook

  • This parameter’s value is computed by a function: num_diag/max(scr,num_diag)

  • Depends on:

    • “Screened”

    • “Annual number of new diagnoses”

  • Description:

  • Data entry guidance:

Parameter: Annual number newly initiated onto treatment

  • Code name: num_initiate

  • Units/format: number

  • Value restrictions: At least 0

  • Default value: None

  • Appears in the databook

  • Used to compute:

    • “Initiation rate”

  • Description:

  • Data entry guidance:

Parameter: Initiation rate

  • Code name: initiate

  • Value can be used for calibration

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Contributes to transitions from:

    • “Diagnosed” to “Treated”

  • Default value: None

  • Does not appear in the databook

  • This parameter’s value is computed by a function: num_initiate/max(dx,num_initiate)

  • Depends on:

    • “Diagnosed”

    • “Annual number newly initiated onto treatment”

  • Description:

  • Data entry guidance:

Parameter: Mortality rate

  • Code name: death

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Contributes to transitions from:

    • “Without cervical cancer” to “Dead (other)”

    • “Undiagnosed” to “Dead (other)”

    • “Screened” to “Dead (other)”

    • “Diagnosed” to “Dead (other)”

    • “Treated” to “Dead (other)”

  • Default value: 0.015

  • Appears in the databook

  • Description:

  • Data entry guidance:

Parameter: Mortality rate for those with untreated cervical cancer

  • Code name: death_cc

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Contributes to transitions from:

    • “Undiagnosed” to “Dead (cervical cancer)”

    • “Screened” to “Dead (cervical cancer)”

    • “Diagnosed” to “Dead (cervical cancer)”

  • Default value: 0.05

  • Appears in the databook

  • Description:

  • Data entry guidance:

Interactions

Cascades

Cascade: Cervical cancer cascade

  • Description:

  • Stages:

    • All women with cervical cancer

      • Estimated number of women with cervical cancer

    • Ever screened

      • Estimated number of women with cervical cancer who have ever been screened

    • Ever diagnosed

      • Estimated number of women with cervical cancer who have ever been diagnosed

    • Currently treated

      • Estimated number of women being treated for cervical cancer