Cervical cancer¶

Name: Cervical cancer

Description: Framework for a 4-stage cervical cancer cascade model, with vital dynamics and new cases

Contents¶

Compartments
Characteristics
Parameters
Interactions
Cascades

Compartments¶

Compartment: Source¶

Code name: source
Is source
Does not appear in the databook
Description:
Data entry guidance:

Compartment: Without cervical cancer¶

Code name: sus
Does not appear in the databook
Description:
Data entry guidance:

Compartment: Undiagnosed¶

Code name: undx
Does not appear in the databook
Description:
Data entry guidance:

Compartment: Screened¶

Code name: scr
Does not appear in the databook
Description:
Data entry guidance:

Compartment: Diagnosed¶

Code name: dx
Does not appear in the databook
Description:
Data entry guidance:

Compartment: Treated¶

Code name: tx
Does not appear in the databook
Description:
Data entry guidance:

Compartment: Dead (other)¶

Code name: dead
Is sink
Does not appear in the databook
Description:
Data entry guidance:

Compartment: Dead (cervical cancer)¶

Code name: dead_cc
Is sink
Does not appear in the databook
Description:
Data entry guidance:

Characteristics¶

Characteristic: Population size¶

Code name: alive
Value can be used for calibration
Includes:
- Without cervical cancer
- Undiagnosed
- Screened
- Diagnosed
- Treated
Appears in the databook
Databook values will be used for model initialization
Description:
Data entry guidance:

Characteristic: Estimated number of women with cervical cancer¶

Code name: all_people
Value can be used for calibration
Includes:
- Undiagnosed
- Screened
- Diagnosed
- Treated
Appears in the databook
Databook values will be used for model initialization
Description:
Data entry guidance:

Characteristic: Estimated number of women with cervical cancer who have ever been screened¶

Code name: all_screened
Value can be used for calibration
Includes:
- Screened
- Diagnosed
- Treated
Appears in the databook
Databook values will be used for model initialization
Description:
Data entry guidance:

Characteristic: Estimated number of women with cervical cancer who have ever been diagnosed¶

Code name: all_dx
Value can be used for calibration
Includes:
- Diagnosed
- Treated
Appears in the databook
Databook values will be used for model initialization
Description:
Data entry guidance:

Characteristic: Estimated number of women being treated for cervical cancer¶

Code name: all_tx
Value can be used for calibration
Includes:
- Treated
Appears in the databook
Databook values will be used for model initialization
Description:
Data entry guidance:

Parameters¶

Parameter: Annual number of births¶

Code name: birth_rate
Units/format: number
Value restrictions: At least 0
Contributes to transitions from:
- “Source” to “Without cervical cancer”
Default value: None
Appears in the databook
Description:
Data entry guidance:

Parameter: Estimated number of new cervical cancer cases annually¶

Code name: num_acq
Units/format: number
Value restrictions: At least 0
Default value: None
Appears in the databook
Used to compute:
- “Acquisition rate”
Description:
Data entry guidance:

Parameter: Acquisition rate¶

Code name: acq_rate
Value can be used for calibration
Units/format: probability
Value restrictions: 0-1.0000
Contributes to transitions from:
- “Without cervical cancer” to “Undiagnosed”
Default value: None
Does not appear in the databook
This parameter’s value is computed by a function: num_acq/max(sus,num_acq)
Depends on:
- “Estimated number of new cervical cancer cases annually”
- “Without cervical cancer”
Description:
Data entry guidance:

Parameter: Annual number screened¶

Code name: num_screen
Units/format: number
Value restrictions: At least 0
Default value: None
Appears in the databook
Used to compute:
- “Annual number screened positive”
Description:
Data entry guidance:

Parameter: Screening yield¶

Code name: screen_yield
Units/format: probability
Value restrictions: 0-1.0000
Default value: None
Does not appear in the databook
This parameter’s value is computed by a function: undx/(undx+sus)
Depends on:
- “Without cervical cancer”
- “Undiagnosed”
Used to compute:
- “Annual number screened positive”
Description:
Data entry guidance:

Parameter: Annual number screened positive¶

Code name: pos_screen
Units/format: number
Value restrictions: At least 0
Default value: None
Does not appear in the databook
This parameter’s value is computed by a function: num_screen*screen_yield
Depends on:
- “Annual number screened”
- “Screening yield”
Used to compute:
- “Screening sensitivity”
Description:
Data entry guidance:

Parameter: Screening sensitivity¶

Code name: screen
Value can be used for calibration
Units/format: probability
Value restrictions: 0-1.0000
Contributes to transitions from:
- “Undiagnosed” to “Screened”
Default value: None
Does not appear in the databook
This parameter’s value is computed by a function: pos_screen/max(undx,pos_screen)
Depends on:
- “Annual number screened positive”
- “Undiagnosed”
Description:
Data entry guidance:

Parameter: Annual number of new diagnoses¶

Code name: num_diag
Units/format: number
Value restrictions: At least 0
Default value: None
Appears in the databook
Used to compute:
- “Probability of a positive confirmation following screening”
Description:
Data entry guidance:

Parameter: Probability of a positive confirmation following screening¶

Code name: diag
Value can be used for calibration
Units/format: probability
Value restrictions: 0-1.0000
Contributes to transitions from:
- “Screened” to “Diagnosed”
Default value: None
Does not appear in the databook
This parameter’s value is computed by a function: num_diag/max(scr,num_diag)
Depends on:
- “Screened”
- “Annual number of new diagnoses”
Description:
Data entry guidance:

Parameter: Annual number newly initiated onto treatment¶

Code name: num_initiate
Units/format: number
Value restrictions: At least 0
Default value: None
Appears in the databook
Used to compute:
- “Initiation rate”
Description:
Data entry guidance:

Parameter: Initiation rate¶

Code name: initiate
Value can be used for calibration
Units/format: probability
Value restrictions: 0-1.0000
Contributes to transitions from:
- “Diagnosed” to “Treated”
Default value: None
Does not appear in the databook
This parameter’s value is computed by a function: num_initiate/max(dx,num_initiate)
Depends on:
- “Diagnosed”
- “Annual number newly initiated onto treatment”
Description:
Data entry guidance:

Parameter: Mortality rate¶

Code name: death
Units/format: probability
Value restrictions: 0-1.0000
Contributes to transitions from:
- “Without cervical cancer” to “Dead (other)”
- “Undiagnosed” to “Dead (other)”
- “Screened” to “Dead (other)”
- “Diagnosed” to “Dead (other)”
- “Treated” to “Dead (other)”
Default value: 0.015
Appears in the databook
Description:
Data entry guidance:

Parameter: Mortality rate for those with untreated cervical cancer¶

Code name: death_cc
Units/format: probability
Value restrictions: 0-1.0000
Contributes to transitions from:
- “Undiagnosed” to “Dead (cervical cancer)”
- “Screened” to “Dead (cervical cancer)”
- “Diagnosed” to “Dead (cervical cancer)”
Default value: 0.05
Appears in the databook
Description:
Data entry guidance:

Interactions¶

Cascades¶

Cascade: Cervical cancer cascade¶

Description:
Stages:
- All women with cervical cancer
  - Estimated number of women with cervical cancer
- Ever screened
  - Estimated number of women with cervical cancer who have ever been screened
- Ever diagnosed
  - Estimated number of women with cervical cancer who have ever been diagnosed
- Currently treated
  - Estimated number of women being treated for cervical cancer