Diabetes

Name: Diabetes

Description: Framework for a diabetes model, including vital dynamics and new cases

Compartments

Compartment: Source

  • Code name: source

  • Is source

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Susceptible

  • Code name: sus

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Unaware & uncomplicated

  • Code name: unsc_uncomp

  • Value can be used for calibration

  • Appears in the databook

  • Description:

  • Data entry guidance:

Compartment: Unaware & vascular damage

  • Code name: unsc_vd

  • Value can be used for calibration

  • Appears in the databook

  • Databook values will be used for model initialization

  • Description:

  • Data entry guidance:

Compartment: Screened & uncomplicated

  • Code name: sc_uncomp

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Screened & vascular damage

  • Code name: sc_vd

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Diagnosed & uncomplicated

  • Code name: dx_uncomp

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Diagnosed & vascular damage

  • Code name: dx_vd

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Successful treatment & uncomplicated

  • Code name: txs_uncomp

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Successful treatment & vascular damage

  • Code name: txs_vd

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Treatment failure & uncomplicated

  • Code name: txf_uncomp

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Treatment failure & vascular damage

  • Code name: txf_vd

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Dead (diabetes)

  • Code name: dead_dm

  • Is sink

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Compartment: Dead (other)

  • Code name: dead_other

  • Is sink

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Characteristics

Characteristic: Population size

  • Code name: alive

  • Value can be used for calibration

  • Includes:

    • Susceptible

    • Unaware & uncomplicated

    • Unaware & vascular damage

    • Screened & uncomplicated

    • Screened & vascular damage

    • Diagnosed & uncomplicated

    • Diagnosed & vascular damage

    • Successful treatment & uncomplicated

    • Successful treatment & vascular damage

    • Treatment failure & uncomplicated

    • Treatment failure & vascular damage

  • Appears in the databook

  • Databook values will be used for model initialization

  • Description:

  • Data entry guidance:

Characteristic: All people with T2DM

  • Code name: ch_all

  • Value can be used for calibration

  • Includes:

    • Unaware & uncomplicated

    • Unaware & vascular damage

    • Screened & uncomplicated

    • Screened & vascular damage

    • Diagnosed & uncomplicated

    • Diagnosed & vascular damage

    • Successful treatment & uncomplicated

    • Successful treatment & vascular damage

    • Treatment failure & uncomplicated

    • Treatment failure & vascular damage

  • Appears in the databook

  • Databook values will be used for model initialization

  • Description:

  • Data entry guidance:

Characteristic: People screened for T2DM

  • Code name: ch_screened

  • Value can be used for calibration

  • Includes:

    • Screened & uncomplicated

    • Screened & vascular damage

    • Diagnosed & uncomplicated

    • Diagnosed & vascular damage

    • Successful treatment & uncomplicated

    • Successful treatment & vascular damage

    • Treatment failure & uncomplicated

    • Treatment failure & vascular damage

  • Appears in the databook

  • Databook values will be used for model initialization

  • Description:

  • Data entry guidance:

Characteristic: People diagnosed with T2DM

  • Code name: ch_diag

  • Value can be used for calibration

  • Includes:

    • Diagnosed & uncomplicated

    • Diagnosed & vascular damage

    • Successful treatment & uncomplicated

    • Successful treatment & vascular damage

    • Treatment failure & uncomplicated

    • Treatment failure & vascular damage

  • Appears in the databook

  • Databook values will be used for model initialization

  • Description:

  • Data entry guidance:

Characteristic: People treated for T2DM

  • Code name: ch_tx

  • Value can be used for calibration

  • Includes:

    • Successful treatment & uncomplicated

    • Successful treatment & vascular damage

    • Treatment failure & uncomplicated

    • Treatment failure & vascular damage

  • Appears in the databook

  • Databook values will be used for model initialization

  • Description:

  • Data entry guidance:

Characteristic: People with HbA1c control

  • Code name: ch_succ

  • Value can be used for calibration

  • Includes:

    • Successful treatment & uncomplicated

    • Successful treatment & vascular damage

  • Appears in the databook

  • Databook values will be used for model initialization

  • Description:

  • Data entry guidance:

Characteristic: Proportion screened for T2DM

  • Code name: ch_propscreened

  • Includes:

    • People screened for T2DM

  • Denominator: All people with T2DM

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Characteristic: Proportion diagnosed with T2DM

  • Code name: ch_propdiag

  • Includes:

    • People diagnosed with T2DM

  • Denominator: All people with T2DM

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Characteristic: Proportion treated for T2DM

  • Code name: ch_proptx

  • Includes:

    • People treated for T2DM

  • Denominator: All people with T2DM

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Characteristic: Proportion with HbA1c control

  • Code name: ch_propsucc

  • Includes:

    • People with HbA1c control

  • Denominator: All people with T2DM

  • Does not appear in the databook

  • Description:

  • Data entry guidance:

Parameters

Parameter: Annual number of births

  • Code name: birth_rate

  • Units/format: number

  • Value restrictions: At least 0

  • Contributes to transitions from:

    • “Source” to “Susceptible”

  • Default value: 15828

  • Appears in the databook

  • Description:

  • Data entry guidance:

Parameter: Estimated number of new diabetes cases annually

  • Code name: num_acq

  • Units/format: number

  • Value restrictions: At least 0

  • Default value: None

  • Appears in the databook

  • Used to compute:

    • “Acquisition rate”

  • Description:

  • Data entry guidance:

Parameter: Acquisition rate

  • Code name: acq_rate

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Contributes to transitions from:

    • “Susceptible” to “Unaware & uncomplicated”

  • Default value: None

  • Does not appear in the databook

  • This parameter’s value is computed by a function: num_acq/max(sus,num_acq)

  • Depends on:

    • “Estimated number of new diabetes cases annually”

    • “Susceptible”

  • Description:

  • Data entry guidance:

Parameter: Time before progression to vascular damage

  • Code name: prog_rate

  • Units/format: duration

  • Value restrictions: At least 0

  • Contributes to transitions from:

    • “Unaware & uncomplicated” to “Unaware & vascular damage”

    • “Screened & uncomplicated” to “Screened & vascular damage”

    • “Diagnosed & uncomplicated” to “Diagnosed & vascular damage”

    • “Treatment failure & uncomplicated” to “Treatment failure & vascular damage”

  • Default value: 1

  • Appears in the databook

  • Description:

  • Data entry guidance:

Parameter: Annual number screened

  • Code name: num_screen

  • Units/format: number

  • Value restrictions: At least 0

  • Default value: None

  • Appears in the databook

  • Used to compute:

    • “Annual number screened positive”

  • Description:

  • Data entry guidance:

Parameter: Yield among those screened

  • Code name: screen_yield

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Default value: None

  • Does not appear in the databook

  • This parameter’s value is computed by a function: (unsc_uncomp+unsc_vd)/(unsc_uncomp+unsc_vd+sus)

  • Depends on:

    • “Unaware & uncomplicated”

    • “Susceptible”

    • “Unaware & vascular damage”

  • Used to compute:

    • “Annual number screened positive”

  • Description:

  • Data entry guidance:

Parameter: Annual number screened positive

  • Code name: pos_screen

  • Units/format: number

  • Value restrictions: At least 0

  • Default value: None

  • Does not appear in the databook

  • This parameter’s value is computed by a function: num_screen*screen_yield

  • Depends on:

    • “Annual number screened”

    • “Yield among those screened”

  • Used to compute:

    • “Screening sensitivity”

  • Description:

  • Data entry guidance:

Parameter: Screening sensitivity

  • Code name: screen

  • Value can be used for calibration

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Contributes to transitions from:

    • “Unaware & uncomplicated” to “Screened & uncomplicated”

    • “Unaware & vascular damage” to “Screened & vascular damage”

  • Default value: None

  • Does not appear in the databook

  • This parameter’s value is computed by a function: pos_screen/max(unsc_uncomp+unsc_vd,pos_screen)

  • Depends on:

    • “Unaware & uncomplicated”

    • “Annual number screened positive”

    • “Unaware & vascular damage”

  • Description:

  • Data entry guidance:

Parameter: Annual number of new diagnoses

  • Code name: num_diag

  • Units/format: number

  • Value restrictions: At least 0

  • Default value: None

  • Appears in the databook

  • Used to compute:

    • “Diagnosis sensitivity”

  • Description:

  • Data entry guidance:

Parameter: Diagnosis sensitivity

  • Code name: diag

  • Value can be used for calibration

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Contributes to transitions from:

    • “Screened & uncomplicated” to “Diagnosed & uncomplicated”

    • “Screened & vascular damage” to “Diagnosed & vascular damage”

  • Default value: None

  • Does not appear in the databook

  • This parameter’s value is computed by a function: num_diag/max(sc_uncomp+sc_vd,num_diag)

  • Depends on:

    • “Screened & vascular damage”

    • “Annual number of new diagnoses”

    • “Screened & uncomplicated”

  • Description:

  • Data entry guidance:

Parameter: Annual number newly initiated onto treatment

  • Code name: num_initiate

  • Units/format: number

  • Value restrictions: At least 0

  • Default value: None

  • Appears in the databook

  • Used to compute:

    • “Initiation rate”

  • Description:

  • Data entry guidance:

Parameter: Initiation rate

  • Code name: initiate

  • Value can be used for calibration

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Contributes to transitions from:

    • “Diagnosed & uncomplicated” to “Successful treatment & uncomplicated”

    • “Diagnosed & vascular damage” to “Successful treatment & vascular damage”

  • Default value: None

  • Does not appear in the databook

  • This parameter’s value is computed by a function: num_initiate/max(dx_uncomp+dx_vd,num_initiate)

  • Depends on:

    • “Diagnosed & uncomplicated”

    • “Diagnosed & vascular damage”

    • “Annual number newly initiated onto treatment”

  • Description:

  • Data entry guidance:

Parameter: Treatment failure rate

  • Code name: treat_fail

  • Value can be used for calibration

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Contributes to transitions from:

    • “Successful treatment & uncomplicated” to “Treatment failure & uncomplicated”

    • “Successful treatment & vascular damage” to “Treatment failure & vascular damage”

  • Default value: 0.5

  • Appears in the databook

  • Description:

  • Data entry guidance:

Parameter: Proportion of those experiencing treatment failure who are offered support

  • Code name: treat_suc

  • Value can be used for calibration

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Contributes to transitions from:

    • “Treatment failure & uncomplicated” to “Successful treatment & uncomplicated”

    • “Treatment failure & vascular damage” to “Successful treatment & vascular damage”

  • Default value: None

  • Appears in the databook

  • Description:

  • Data entry guidance:

Parameter: Death rate for diabetes with vascular damage

  • Code name: death_vd

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Contributes to transitions from:

    • “Unaware & vascular damage” to “Dead (diabetes)”

    • “Screened & vascular damage” to “Dead (diabetes)”

    • “Diagnosed & vascular damage” to “Dead (diabetes)”

    • “Successful treatment & vascular damage” to “Dead (diabetes)”

    • “Treatment failure & vascular damage” to “Dead (diabetes)”

  • Default value: 0.025

  • Appears in the databook

  • Description:

  • Data entry guidance:

Parameter: Background mortality rate

  • Code name: death_other

  • Units/format: probability

  • Value restrictions: 0-1.0000

  • Contributes to transitions from:

    • “Susceptible” to “Dead (other)”

    • “Unaware & uncomplicated” to “Dead (other)”

    • “Unaware & vascular damage” to “Dead (other)”

    • “Screened & uncomplicated” to “Dead (other)”

    • “Screened & vascular damage” to “Dead (other)”

    • “Diagnosed & uncomplicated” to “Dead (other)”

    • “Diagnosed & vascular damage” to “Dead (other)”

    • “Successful treatment & uncomplicated” to “Dead (other)”

    • “Successful treatment & vascular damage” to “Dead (other)”

    • “Treatment failure & uncomplicated” to “Dead (other)”

    • “Treatment failure & vascular damage” to “Dead (other)”

  • Default value: 0.015

  • Appears in the databook

  • Description:

  • Data entry guidance:

Interactions

Cascades

Cascade: Diabetes care cascade

  • Description:

  • Stages:

    • All people with T2DM

      • Unaware & uncomplicated

      • Unaware & vascular damage

      • Screened & uncomplicated

      • Screened & vascular damage

      • Diagnosed & uncomplicated

      • Diagnosed & vascular damage

      • Successful treatment & uncomplicated

      • Successful treatment & vascular damage

      • Treatment failure & uncomplicated

      • Treatment failure & vascular damage

    • Screened

      • Screened & uncomplicated

      • Screened & vascular damage

      • Diagnosed & uncomplicated

      • Diagnosed & vascular damage

      • Successful treatment & uncomplicated

      • Successful treatment & vascular damage

      • Treatment failure & uncomplicated

      • Treatment failure & vascular damage

    • Diagnosed

      • Diagnosed & uncomplicated

      • Diagnosed & vascular damage

      • Successful treatment & uncomplicated

      • Successful treatment & vascular damage

      • Treatment failure & uncomplicated

      • Treatment failure & vascular damage

    • Treated

      • Successful treatment & uncomplicated

      • Successful treatment & vascular damage

      • Treatment failure & uncomplicated

      • Treatment failure & vascular damage

    • HbA1c control

      • Successful treatment & uncomplicated

      • Successful treatment & vascular damage

Cascade: Diabetes care cascade - vascular damage

  • Description:

  • Stages:

    • All people

      • Unaware & vascular damage

      • Screened & vascular damage

      • Diagnosed & vascular damage

      • Successful treatment & vascular damage

      • Treatment failure & vascular damage

    • Screened

      • Screened & vascular damage

      • Diagnosed & vascular damage

      • Successful treatment & vascular damage

      • Treatment failure & vascular damage

    • Diagnosed

      • Diagnosed & vascular damage

      • Successful treatment & vascular damage

      • Treatment failure & vascular damage

    • Treated

      • Successful treatment & vascular damage

      • Treatment failure & vascular damage

    • HbA1c control

      • Successful treatment & vascular damage

Cascade: Diabetes care cascade - uncomplicated cases

  • Description:

  • Stages:

    • All people

      • Unaware & uncomplicated

      • Screened & uncomplicated

      • Diagnosed & uncomplicated

      • Successful treatment & uncomplicated

      • Treatment failure & uncomplicated

    • Screened

      • Screened & uncomplicated

      • Diagnosed & uncomplicated

      • Successful treatment & uncomplicated

      • Treatment failure & uncomplicated

    • Diagnosed

      • Diagnosed & uncomplicated

      • Successful treatment & uncomplicated

      • Treatment failure & uncomplicated

    • Treated

      • Successful treatment & uncomplicated

      • Treatment failure & uncomplicated

    • HbA1c control

      • Successful treatment & uncomplicated